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Nicola M Gardner Selected Research

Neoplasms (Cancer)

12/2016Structural Determinants of the Dictyostatin Chemotype for Tubulin Binding Affinity and Antitumor Activity Against Taxane- and Epothilone-Resistant Cancer Cells.
2/2011Total synthesis and biological evaluation of a series of macrocyclic hybrids and analogues of the antimitotic natural products dictyostatin, discodermolide, and taxol.
3/2009Total synthesis and biological evaluation of novel C2-C6 region analogues of dictyostatin.
12/2008Total synthesis and biological evaluation of potent analogues of dictyostatin: modification of the C2-C6 dienoate region.
3/2008Synthesis and biological evaluation of 10,11-dihydrodictyostatin, a potent analogue of the marine anticancer agent dictyostatin.
5/2007Synthesis and biological evaluation of novel analogues of dictyostatin.
1/2007Design, synthesis and biological evaluation of a macrocyclic discodermolide/dictyostatin hybrid.

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Nicola M Gardner Research Topics

Disease

7Neoplasms (Cancer)
12/2016 - 01/2007
1Neurodegenerative Diseases (Neurodegenerative Disease)
09/2013
1Tauopathies
09/2013
1Alzheimer Disease (Alzheimer's Disease)
09/2013

Drug/Important Bio-Agent (IBA)

6dictyostatinIBA
12/2016 - 01/2007
5Paclitaxel (Taxol)FDA LinkGeneric
02/2011 - 05/2007
2AldehydesIBA
03/2009 - 12/2008
2discodermolideIBA
05/2007 - 01/2007
1Epothilones (Epothilone)IBA
12/2016
1taxaneIBA
12/2016
1TubulinIBA
12/2016
1Excipients (Suspending Agents)IBA
09/2013
1desoxyepothilone B (epothilone D)IBA
09/2013
1tau Proteins (tau Protein)IBA
09/2013
1Member 1 Subfamily B ATP Binding Cassette TransporterIBA
03/2009
1beta-ketophosphonateIBA
12/2008
1MacrolidesIBA
12/2008
110,11-dihydrodictyostatinIBA
03/2008